Obesity, type 2 diabetes, and cancer: the insulin and IGF connection.
نویسندگان
چکیده
Epidemiological studies suggest a positive association between obesity and type 2 diabetes mellitus (T2D) with the risk of cancer and cancer-related mortality. Insulin resistance, hyperinsulinemia, increased levels of IGF, elevated levels of steroid and peptide hormones, and inflammatory markers appear to play a role in the connection between these different diseases. Medications, such as metformin and exogenous insulin, used to treat T2D may affect the risk of cancer and cancer-related mortality. Newer therapies targeting the insulin and IGF1 systems are being developed for use in cancer therapy.
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ورودعنوان ژورنال:
- Endocrine-related cancer
دوره 19 5 شماره
صفحات -
تاریخ انتشار 2012